SPOTNEWS
PO Box 257
Marengo IL, 60152-0257
“UROLITHIASIS,
BLADDER
STONES
AND CRYSTALS”
ANOTHER
POINT
OF VIEW
By
Carroll H. Weiss
Former Director, 1991-2002
DCA Study Group on Urinary Stones
“Urolithiasis,
Bladder Stones and Crystals,” an
article by Lew Olson appeared in the January 2003 issue of Chicagoland’s
excellent newsletter, SPOTNEWS. A few of the author’s recommendations about
urinary stone disease have credibility. However, other generalities, statements
and recommendations for canine stone disease are scientifically incorrect, some
misleading and most lack any supportive medical evidence. Applying some may not
adversely affect Dalmatians so long as the dogs are accurately confirmed with
struvites, nicknamed “infection stones.” And “accurately” because up to 85%
error in stone assay was reported.
Tangible veterinary data in one report linked
to the DCA homepage on almost 3,000 Dalmatian stones showed almost 2,700 were
purine/urates, the breed-specific type. In stark contrast were a scanty 29
struvites, the type occupying most of the SPOTNEWS article despite struvites, as
in this data study, not being Dalmatian-prevalent at all. Urates are barely
discussed. Readers who incorrectly or carelessly follow the article’s
recommendations can seriously worsen Dalmatians with the breed-prevalent urate
stone disease.
The science compelling my challenges exists
via a now extraordinary clinical database gathered from 11,000 stone-forming
dogs by the two world-famous U.S. veterinary medicine centers specializing in
canine urolithiasis. Anyone may read and evaluate decades of their scientific
evidence as published in accredited vet journals, in veterinary medicine
textbooks and on the DCA home page. The purpose of this rebuttal is to provide
readers with canine stone disease information only from veterinary medicine so
any unquestioning acceptance of the SPOTNEWS article can be balanced with
authenticated scientific facts. Readers can then make at least an informed
choice.
The author’s introductory byline states,
“PhD. Natural Health.” This immediately alerted me her thrust
probably would be, as her article indeed confirmed, to so-called “natural”
foods, herbs and alternatives. I have learned to approach their health
allegations with disbelief unless documented with scientific evidence. The
article was no exception. So, please start with:
1. Dalmatians are the only breed of dog with
the genetic defect in their livers and kidneys leading to possible urate stone
disease. All Dalmatians have the defect. The absolute worst-case-scenario of
canine stone disease is the life-threatening “urinary obstruction” produced by
one or more stones blocking the normal pathway of urinating. When obstructed,
ongoing urine production backs up into the Dalmatian’s body. Untreated or
unnoticed, the obstructed dog can be dead within two or three days by bursting
its bladder or kidney malfunctioning.
2. So-called “natural” remedies are not legally
required to provide scientific evidence for their promotional claims nor to
announce side effects, because they are not classified as medications. Not
surprisingly, therefore, most provide no proof nor cautions yet do not hesitate
making extravagant health allegations. Laws currently governing the U.S. Food &
Drug Administration (FDA) do not permit the agency to enforce a
“cease-and-desist” on alternatives’ allegations in order to protect patients,
human or canine. In fairness, I happily acknowledge that one or two of these
unregulated chemicals are nonetheless accumulating doctors’ support of their
health claims, such as clinical data by rheumatologists in accredited journals
of the chondroitin-glucosamine formulations for certain musculoskeletal
problems. In contrast, shark cartilage was repetitively proven worthless for
cancer in several clinical studies by the U.S. National Institutes of Health.
Still others are being flagged by mass media because of alarming dangers as
their widespread but indiscriminate use increases. It seems only when deaths or
life-threatening side effects occur that the public starts learning of possible
harmful aspects of alternatives and “natural” remedies, but rarely from those
who profit from them. As I write this, prime time news media are reporting a
campaign against ephedra, championed by a New York State mother
convinced it was responsible for her son’s death. Nonetheless, it is only when
proponents of alternative medicine target Dalmatian stone disease with medically
incorrect, scientifically misleading, or unproven allegations which veterinary
evidence indicates will endanger breed-specific urate-forming Dalmatians that I
step forward to challenge. The dreaded specter of urinary obstruction, alone,
compels me to warn Dalmatian owners in an “equal time” mode, such as this
retort.
I approached the article with admitted
prejudice. I started reading by being surprisingly relieved with its responsible
mention of the importance (1) to accurately identify the type of stone, (2) the
influence of copious water drinking, leading to (3) the need for the dog to
frequently urinate and (4) the value of monitoring urinary pH. Continuing on,
however, I quickly became dismayed as some of my admitted prejudices were
reinforced. I first booted up the websites her article recommended.
Item - Of several, one boasted,
“Alternative Medicine [is] A multi-million dollar business;...”
This web site went on to offer readers “A
Complete Retail Store [merchandising alternative medicine] Yours
For a Minimal Investment ... $20,000...”
This to me is a revealing sign, namely
seductive profits appear to be the major underlying motive to popularize
expensively-priced alternatives even though promoting them rarely if ever
includes volunteering information about their known side effects. The SPOTNEWS
article ends with the author’s own seminar notice and the stipulation it costs
$65.00 per person to attend. I personally find that fee expensive to hear
medical claims few if any of which have the slightest scientific evidence to
support their truth for Dalmatian stone disease.
Item - “DOCTOR YOURSELF!” is the
dramatized name of a self-diagnosing, self-prescribing website recommended by
the article. I burst out laughing after reading to the end and finding
its legal disclaimer: “Persons needing
medical care should obtain it from a
physician. Consult your doctor before making
any health decision.” So much
for its medical credibility. Case closed.
Item - As another contradiction, the author’s
seminar notice states, presumably as enticement to pay the registration fee,
“...learn ABOUT...THE USE OF A RAW DIET...” Contrary to the seminar’s
emphasis, another website recommended by her article emphatically warns, also
using solid capitals,
“...For uric acid/purine stones (gout),
STOP EATING MEAT! Nutrition tables and textbooks indicate meats as the major
dietary purine source.”
Again,
I’d find $65.00 expensive to sit and be told such contradictions. I also
doubt the seminar will volunteer how anecdotal evidence against a raw diet was
started when two reports by pet owners last year to a BARF online list told of
their stone-forming dogs going into urinary obstruction after being shifted to
the raw diet.
The recommended websites prompted only the
beginning of my objections. Some of the article’s statements also require
cautioning if readers casually apply them to any stone-forming Dalmatian, even
though the article spotlights struvite stone disease.
“...they
[urinary
stones] can fill the bladder in some cases, resulting in the need for
surgical removal.”
Emergency surgery is required not by stones
“filling” the dog’s bladder but by life-threatening obstruction of the normal
urinary stream, regardless of how few or how many stones cause it.
Obstruction in stone-forming dogs mostly occurs
within the penis at a dam-like cartilage, the “os penis,” not within the
bladder. Further, many stone-forming Dalmatians have been obstructed by merely a
single stone or only two or three without any others seen in the bladder at all.
“Struvites are almost always
accompanied by bacteria that create a high alkaline pH.”
The medical perspective is wrong. Stone-forming
bacteria are the predominate cause of struvite stone disease. It is not
coincidence that bacteria “almost always accompany” the stones -
the bacteria create them! Innumerable dogs, Dalmatians included, develop urinary
tract infections (UTIs) but never struvite stones if the infecting bacteria are
not stone-forming species. The three bacteria usually causing UTIs are
Staphylococcus, Pseudomonas and E. coli. Of the three,
E. coli-caused UTIs are the most common but, happily, E. coli
is not a stone-forming bacterium! (The other two are stone-forming species.)
Whether for infection stones or for just a UTI, acidifying urine - without
antibiotics - cannot kill bacteria nor cure a confirmed UTI nor dissolve
struvites. Feeding cranberries or cherries, as cited in the article to “prevent”
chronic UTI and struvites, is conjecture; there is no scientific confirmation
they do. Even then, any indiscriminate acidifying of Dalmatian urine is to be
avoided because abnormally acidic urine accelerates the onset and progress of
the breed-specific urate stone disease. Besides, reversal of struvite disease is
by primary treatment with an effective antibiotic, not by urinary acidifiers
considered only a secondary adjunct, albeit helpful. The world-famous Minnesota
Stone Center cautions, as struvites are slowly dissolved by antibiotics, they
usually release embedded bacteria from within the stones back into the urine,
keeping the UTI “alive.” Accordingly, the antibiotic should not be discontinued
prematurely or the UTI will recur, unchecked. With this said, any altering of
the abnormal alkalinity by only urinary acidifiers or acid-producing foods again
would have little or no effect without, first, antibiotics continued until the
struvite stones are totally dissolved.
“...many dogs can have
struvites present in the urine...with no ill effects, so if a routine urinalysis
shows a pH of 8.0 and a few struvite crystals, but your dog has no symptoms of
any kind, there is no need to be concerned.”
This dangerous reassurance reveals a lack of
serious facts about canine stone disease, and alarmed me the most.
Life-threatening urinary obstruction often occurs in Dalmatians who previously
reveal no warning symptoms to their unsuspecting owners. The Minnesota Stone
Center uses the term “silent stone formers” for such dogs. It
takes only one stone (of any type) slowly increasing in size in a silent stone
former abruptly to finally obstruct its urinary stream one day, immediately
jeopardizing the dog’s life and without any prior alert to its owner. With
simple, inexpensive tests (like urinalyses and dipsticking for urinary pH) to
regularly monitor warning signals well-in-advance, why complacently wait until
the Dalmatian obstructs and then requires emergency surgery - or is euthanized
if the cost cannot be paid to save its life?
“Some people have had
success...by feeding acidic foods and avoiding alkaline foods. A raw, natural
diet is high in acidic foods.”
The author needs to revisit her recommended
website, cited previously, to refresh her memory on their trumpeted
contradiction to her statement. Urate-forming Dalmatians show very acidic urine
because urate-forming thrives in acidic urine. As the only breed of dog with
their inborn defect for urate stone disease, any food worsening the
breed-typical Dalmatians’ acidic urine is to be avoided or minimized as one of
several procedures preventing the breed’s stone disease.
“Alkaline pH and struvite
crystals are...usually caused by bladder infections. Therefore, trying to make
the urine more acidic will not get rid of the infection.”
“...acidifying the diet,
along with treating the infection, can help dissolve the
[struvite]
stones. Ascorbic acid (a form of vitamin C)...can help with this.”
More seeming contradictions. Using urinary
acidifiers for struvite stone-formers (or the reverse, urinary alkalinizers for
urate stone-formers) are helpful adjuncts but only secondary to more definitive
treatment. As a glaring example of how limited knowledge not-in-context of known
anti-stone programs can worsen Dalmatians with urolithiasis, note the longtime
but now-to-be-avoided use of baking soda (sodium bicarbonate). Why do
veterinarian specialists in sone disease stress sodium bicarbonate should
not be used to neutralize Dalmatians’ acidic urine and replaced by other
alkalinizers? Answer:- chemically, the sodium in it can combine to form “sodium
urate” stones, complicating the treatment of whatever other types of stones are
already being formed. Another example of dangerous claims not-in-context:- the
article neglects to warn vitamin C is a chemical precursor for calcium oxalate,
a stone it cautions against but which could have its onset or be worsened by the
conflicting recommendation to use the vitamin.
I sincerely hope alternatives one day can start
to provide tangible medical evidence so their unsupported allegations can begin
to earn scientific credibility. If that ever takes place, I will be the first to
publicly applaud, welcoming the data. Until then, and after 11 years of being
contacted by hundreds of worldwide owners of stone-forming Dalmatians (many in
emergency obstruction), I remain suspicious and distrustful of what I perceive
as irresponsible and ill-informed allegations to use anything except
authenticated veterinary protocols for Dalmatian-specific urinary stone disease.
Readers are reminded of the series of online
teaching articles about our breed’s urate disease on the DCA homepage. Unlike
alternatives’ allegations without medical evidence, these articles were written
using clinical data from the two U.S. veterinary stone disease centers.
OFFICIAL DCA PAMPHLET ON STONE FORMING
(Important note! The latest version of the
Acrobat Reader is required plus legal-size paper.)
URINARY STONE-FORMING IN DALMATIANS & OTHER DOGS
URINARY STONES: 1992 SEMINAR BY DR. JOSEPH
BARTGES
URINARY STONES: DIPSTICKING
TO MONITOR STONE-FORMERS
URINARY STONES: EMERGENCY PROCEDURES FOR
OBSTRUCTED DALS
URINARY STONES: GENERAL PREVENTATIVE PROCEDURES
URINARY STONES: TABULATION OF PURINE-YIELDING
FOODS:
THE FALLACY OF "LOW PROTEIN" VS. "HIGH PROTEIN"
IN DAL DIETS
FIFTEEN YEARS OF DATA ON ALMOST 3,000 DALMATIAN STONES
Page 14 March 2003 CDC
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of Article * * * * * *
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